| 1. | .is | Intermediate assembly file (Modula-3) |
| 2. | .isd | Spelling Checker dictionary (RapidFile) |
| 3. | .ish | Compressed file archive (ISH) |
| 4. | .iso | Bitmap graphics (CALS ISO 8613) ◊ CD Image File (ISO 9660 CD-ROM file system standard) ◊ ISO-9660 table (International Standards Organization) |
| 5. | .isp | Internet Service Provider settings (Microsoft IIS) |
| 6. | .iss | Response file (InstallShield Silent) |
| 7. | .ist | Instrument file (DigitalTracker) ◊ IsoStar Library of intermolecular interactions |
| 8. | .istr | IsoStar Library of intermolecular interactions |
| 9. | .isu | Uninstall script (InstallShield) |
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