| 1. | .sea | Self-extracting compressed Macintosh file archive (Compact Pro) ◊ SoundBlaster effect preset for your sound card |
| 2. | .sec | Diskreet encrypted file (Diskreet) ◊ Secret key ring file (Pretty Good Privacy) ◊ Secured animation file (Disney Animation Studio) |
| 3. | .sed | Screen editor script files (SED) |
| 4. | .sel | Data file (Copy Books) |
| 5. | .sep | Printer separator page |
| 6. | .seq | Animation file (Atari) ◊ Sequential Instruction File (Bubble Chamber) |
| 7. | .ses | Session file (Cool Edit) ◊ Session info (Clarion Modula-2) |
| 8. | .session | Internet Security Scanner file (ISS) |
| 9. | .set | Configuration (1st Reader) ◊ Install driver sets (Symphony) ◊ Setup data or info ◊ Voice set files (Quartet) |
| 10. | .sew | Sewing program file (Generic) |
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