| 11. | .st9 | Status (Spice) |
| 12. | .sta | Data file (Statistica) ◊ Saved state (Reflection 4.0) ◊ Stack (Spinmaker Plus) |
| 13. | .stb | Stub library (Genus GX Kernel) |
| 14. | .std | Standard (something..) (LocoScript) ◊ State Transition Diagram graphics file (Prosa) |
| 15. | .stegano | Steganographic image |
| 16. | .step | ISO-10303 STEP product data |
| 17. | .stf | Compressed file archive (ShrinkToFit) |
| 18. | .stl | Stereolithography Interface Format |
| 19. | .stm | HTML file containing Server Side Includes (SSI) ◊ Music (4 channels) (Scream Tracker II) ◊ State Transition Diagram model file (Prosa) |
| 20. | .stn | geocoding standardization file (ArcView) |
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