| 251. | .step | ISO-10303 STEP product data |
| 252. | .stf | Compressed file archive (ShrinkToFit) |
| 253. | .stl | Stereolithography Interface Format |
| 254. | .stm | HTML file containing Server Side Includes (SSI) ◊ Music (4 channels) (Scream Tracker II) ◊ State Transition Diagram model file (Prosa) |
| 255. | .stn | geocoding standardization file (ArcView) |
| 256. | .sto | Pascal stub OBJ file (Genus GX Kernel) |
| 257. | .stp | ISO-10303 STEP product data |
| 258. | .stq | Text file (Statistica) (StatSoft Software) |
| 259. | .str | Gate3 table structure file ◊ Screensaver file ◊ Structure list object file (dBASE Application Generator) |
| 260. | .sts | Project status info (Microsoft C/C++) ◊ Song format (Scream Tracker) |
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