| 111. | .isp | Internet Service Provider settings (Microsoft IIS) |
| 112. | .iss | Response file (InstallShield Silent) |
| 113. | .ist | Instrument file (DigitalTracker) ◊ IsoStar Library of intermolecular interactions |
| 114. | .istr | IsoStar Library of intermolecular interactions |
| 115. | .isu | Uninstall script (InstallShield) |
| 116. | .it | Music (Impulse Tracker) ◊ Settings (intalk) |
| 117. | .itf | Interface file (JPI TopSpeed Pascal) |
| 118. | .itg | Bitmap graphics (Intergraph Format) |
| 119. | .iti | Instrument file (Impulse Tracker) |
| 120. | .its | Internet Document Set ◊ Music sample (Impulse Tracker) |
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