| 211. | .sqd | Squish message base (Squish) |
| 212. | .sqi | Squish message base index (Squish) |
| 213. | .sql | SQL report or query ◊ Squish message base last read pointers (Squish) |
| 214. | .sqp | Query result of audio search (Sonique) |
| 215. | .sqr | Structured Query Language (SQL) program file |
| 216. | .sqz | Compressed file archive (Squeeze) |
| 217. | .sr | Bitmap graphics (Sun Rasterfile) |
| 218. | .src | A file used in the creation of .INI files for configuration settings. ◊ Source (DataFlex, Multi-Edit) |
| 219. | .sre | Undefined file (Motorola) |
| 220. | .srf | Bitmap graphics (Sun Raster File) |
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