| 51. | .scu | Bitmap graphics (ColoRIX) |
| 52. | .scv | CASmate Native format (ScanVec) |
| 53. | .scx | Bitmap graphics (RIX Softworks Paint Tool ColoRIX file) ◊ Chart (Stanford Chart) ◊ Main (DBF) screen description file (FoxPro) |
| 54. | .scy | Security file (ReaGeniX) |
| 55. | .scz | Data (Wingz) |
| 56. | .sd | Sound (Entropic Sound Data format) ◊ Sound (Sound Designer I audio file) |
| 57. | .sd2 | SAS database ◊ Sound (Sound Designer II data fork) |
| 58. | .sda | Software Distribution Network file archive description |
| 59. | .sdb | Symbol database (Synopsys Design Compiler) |
| 60. | .sdc | Spreadsheet (StarOffice StarCalc) |
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